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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Immunomodulatory effects of the water-soluble lectin from Moringa oleifera seeds (WSMoL) on human peripheral blood mononuclear cells (PBMC).

Abstract Source:

Protein Pept Lett. 2018 Jan 30. Epub 2018 Jan 30. PMID: 29384049

Abstract Author(s):

Marilia Cavalcanti Coriolano, Jessica de Santana Brito, Leydianne Leite de Siqueira Patriota, Ana Karine de Araújo Soares, Patricia Maria Guedes Paiva, Virginia Maria Barros de Lorena, Thiago Henrique Napoleao, Luana Barroso Coelho, Cristiane Moutinho Lagos de Melo

Article Affiliation:

Marilia Cavalcanti Coriolano

Abstract:

Moringa oleifera is used in traditional medicine as well as in food, cosmetic, and pharmaceutical industries. Water-soluble M. oleifera lectin (WSMoL) is an anionic protein isolated from the seeds. This work investigated the immunomodulatory effects of WSMoL on human PBMC. Measurement of cytokine and nitric oxide levels and immunophenotyping assays were investigated. PBMC were incubated with WSMoL (10µg/mL) for 24 h, 48 h and 72 h, and was performed immunophenotyping of lymphocytes and monocytes. Culture supernatants were used to determined cytokine and nitric oxide levels. WSMoL induced the release of the cytokines TNF-a, IL-2, IL-6, IL-10 as well as of nitric oxide. Incubation of PBMC with this lectin also led to activation of CD8+ T lymphocytes. WSMoL promotes immunomodulation in human PBMC inducing a potential wound healing profile and, in future in vivo assays, can be evaluated as adjuvant in immunosuppressive diseases and wound repair.

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Depression: 21st Century Solutions + The Dark Side of Wheat

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