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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Immune Response of Healthy Adults to the Ingested Probiotic Lactobacillus casei Shirota.

Abstract Source:

Scand J Immunol. 2016 Dec ;84(6):353-364. PMID: 27718254

Abstract Author(s):

L S Harbige, E Pinto, J Allgrove, L V Thomas

Article Affiliation:

L S Harbige

Abstract:

Daily ingestion of a probiotic drink containing Lactobacillus casei Shirota (LcS; 1.3× 10live cells) by healthy adults for (1) 4-week LcS, (2) 6-week discontinuation of LcS and (3) a final 4 weeks of LcS was investigated. There was a significant increase in expression of the T cell activation marker CD3CD69in ex vivo unstimulated blood cells at weeks 10 and 14, and there was a significant increase in the NK cell marker CD3CD16/56in ex vivo unstimulated blood cells at weeks 4, 10 and 14. Expression of the NK cell activation marker CD16/56CD69in ex vivo unstimulated blood cells was 62% higher at week 10 and 74% higher at week 14. Intracellular staining of IL-4 in ex vivo unstimulated and PMA-/ionomycin-stimulated CD3β7integrin blood cells was significantly lower at weeks 10 and 14. Intracellular staining of IL-12 in ex vivo unstimulated and LPS-stimulated CD14blood cells was significantly lower at weeks 4, 10 and 14. Intracellular staining of TNF-α in LPS-stimulated CD14blood cells was significantly lower at weeks 4, 10 and 14. Mucosal salivary IFN-γ, IgA1 and IgA2 concentrations were significantly higher at week 14, but LcS did not affect systemic circulating influenza A-specific IgA or IgG and tetanus-specific IgG antibody levels. In addition to the decrease in CD3β7integrin cell IL-4 and a reduced CD14cell pro-inflammatory cytokine profile, at week 14 increased expression of activation markers on circulating T cells and NK cells and higher mucosal salivary IgA1 and IgA2 concentration indicated a secondary boosting effect of LcS.

Study Type : Human Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(1287) : AC(358)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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