Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Hypothyroidism as a protective factor in acute stroke patients.

Abstract Source:

Clin Endocrinol (Oxf). 2006 Sep;65(3):369-72. PMID: 16918958

Abstract Author(s):

Maria Alevizaki, Margaret Synetou, Konstantinos Xynos, Calliope C Alevizaki, Kostas N Vemmos

Article Affiliation:

Endocrine Unit, Department of Medical Therapeutics, Athens University School of Medicine, Athens, Greece. mani@otenet.gr

Abstract:

OBJECTIVE: It has been reported that hypothyroidism is associated with better survival in elderly persons. We investigated possible associations of thyroid status with clinical outcome in patients with acute stroke. DESIGN: Retrospective analysis. PATIENTS: Consecutive patients (median age 70 years) admitted for acute stroke. MEASUREMENTS: Total T3, T4 and TSH levels. Stroke severity evaluation using the Scandinavian Stroke Scale (SSS) and the Glasgow Coma Score (GCS). Handicap and survival assessment over 12 months. RESULTS: Of 744 patients where thyroid function tests were available within the first 24 h of stroke, 13 had elevated TSH (>or= 10 microU/ml; range 10-42 microU/ml) (hypo-group), 51 had mildly elevated TSH (3.3-9.9 microU/ml) and 680 had nonelevated TSH<3.3 microU/ml. In the hypo-group transient ischaemic attacks (TIA's) were more prevalent (46.2%) compared to the groups of mildly elevated TSH (11.8%) and nonelevated TSH (12.4%, P<0.002). Hypo-group had more frequently an adequate level of consciousness (GCS 14-15 = fully alert): 92.3%vs 74.5% and 63.7% (P = 0.033), a milder neurological deficit (SSS score 45-58) 76.9%vs 39.2% and 38.7% (P = 0.02) compared to the other two groups, respectively, and a tendency for lower glucose levels on admission. One year outcome tended to be better with respect to survival and handicap. CONCLUSIONS: Acute stroke patients with laboratory findings compatible with pre-existing hypothyroidism on admission, appear to have better clinical presentation and outcome; we speculate that a reduced response to stress and previous TIA's, possibly related to endogenous 'preconditioning', may contribute to this phenomenon.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.