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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Antioxidant and mercury chelating activity of Psidium guajava var. pomifera L. leaves hydroalcoholic extract.

Abstract Source:

J Toxicol Environ Health A. 2017 Oct 11:1-13. Epub 2017 Oct 11. PMID: 29020526

Abstract Author(s):

Antonio Ivanildo Pinho, Cláudia Sirlene Oliveira, Fabricio Luís Lovato, Emily Pansera Waczuk, Bruna Candia Piccoli, Aline Augusti Boligon, Nadghia Figueredo Leite, Henrique Douglas Melo Coutinho, Thais Posser, João Batista Teixeira Da Rocha, Jeferson Luis Franco

Article Affiliation:

Antonio Ivanildo Pinho

Abstract:

Mercury (Hg) is widely distributed in the environment and is known to produce several adverse effects in organisms. The aim of the present study was to examine the in vitro antioxidant activity and Hg chelating ability of the hydroalcoholic extract of Psidium guajava leaves (HEPG). In addition, the potential protective effects of HEPG against Hg(II) were evaluated using a yeast model (Saccharomyces cerevisiae). HEPG was found to exert significant antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenger and inhibition of lipid peroxidation induced by Fe(II) assays in a concentration-dependent manner. The extract also exhibited significant Hg(II) chelating activity. In yeast, Hg(II) induced a significant decrease in cell viability. In contrast, HEPG partially prevented the fall in cell viability induced by Hg(II). In conclusion, HEPG exhibited protective effects against Hg(II)-mediated toxicity, which may be related to both antioxidant and Hg(II)-chelating activities.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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