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Abstract Title:

Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats.

Abstract Source:

J Sci Food Agric. 2017 Feb 9. Epub 2017 Feb 9. PMID: 28182280

Abstract Author(s):

Si Jing Chen, Chiwa Aikawa, Risa Yoshida, Tomoaki Kawaguchi, Toshiro Matsui

Article Affiliation:

Si Jing Chen

Abstract:

BACKGROUND: Prediabetes, a high-risk state for developing diabetes showing impaired glucose tolerance but a normal fasting blood glucose level, has an increasing prevalence worldwide. However, no study investigating the prevention of impaired glucose tolerance at the prediabetic stage by anti-diabetic functional foods has been reported. Thus, the present study aimed to evaluate the anti-prediabetic effect of rose hip in a prediabetic rat model.

RESULTS: Spontaneously diabetic Torii (SDT) rats were supplemented with hot-water extract of rose hip at a dose of 100 mg kg(-1) body weight day(-1) for 12 weeks. The results obtained showed that the supplementation of rose hip extract improved impaired glucose tolerance, promoted insulin secretion, preserved pancreatic beta-cell function and suppressed plasma advanced glycation end-products formation of methylglyoxal-derived hydroimidazolone (MG-H1) residue and N(ϵ) -carboxymethyl-lysine residues (e.g. MG-H1, control: 465.5 ± 43.8 versus rose hip: 59.1 ± 13.0 pmol mg protein(-1) , P<0.05) in SDT rats at the prediabetic stage (12-20 weeks old).

CONCLUSION: The present study provides the first evidence showing that a hot-water extract of rose hip could exert an anti-prediabetic effect in a rat model.© 2017 Society of Chemical Industry.

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