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Abstract Title:

Colony stimulating factor-inducing activity of hesperidin.

Abstract Source:

Planta Med. 1999 May;65(4):365-6. PMID: 10364845

Abstract Author(s):

K Kawaguchi, S Kikuchi, K Takayanagi, T Yoshikawa, Y Kumazawa

Abstract:

To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6 h before bleeding. All compounds carrying the glucosyl-rhamnose moiety showed potent activity. Among them, hesperidin exhibited the strongest activity. Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later. The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.

Study Type : In Vitro Study

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Sayer Ji
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