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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Essential fatty acid metabolism and its modification in atopic eczema.

Abstract Source:

Am J Clin Nutr. 2000 Jan;71(1 Suppl):367S-72S. PMID: 10617999

Abstract Author(s):

D F Horrobin

Article Affiliation:

Laxdale Research, Stirling, Scotland, United Kingdom. admin@laxdale.co.uk

Abstract:

Research from the 1930s to the 1950s established that a deficit of n-6 essential fatty acids (EFAs) leads to an inflammatory skin condition in both animals and humans. In a common inherited skin condition, atopic dermatitis (eczema), there was evidence of low blood EFA concentrations and of a therapeutic response to exceptionally high doses of linoleic acid. More recently, it has been established that there is no deficit of linoleic acid in atopic eczema. Concentrations of linoleic acid instead tend to be elevated in blood, milk, and adipose tissue of patients with atopic eczema, whereas concentrations of linoleic acid metabolites are substantially reduced. This suggests reduced conversion of linoleic acid to gamma-linolenic acid (GLA). In most but not all studies, administration of GLA has been found to improve the clinically assessed skin condition, the objectively assessed skin roughness, and the elevated blood catecholamine concentrations of patients with atopic eczema. Atopic eczema may be a minor inherited abnormality of EFA metabolism.

Study Type : Human Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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