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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer.

Abstract Source:

Nutr Cancer. 2017 Jan ;69(1):29-43. Epub 2016 Nov 28. PMID: 27892708

Abstract Author(s):

Eliana Noelia Alonso, María Julia Ferronato, Norberto Ariel Gandini, María Eugenia Fermento, Diego Javier Obiol, Alejandro López Romero, Julián Arévalo, María Emilia Villegas, María Marta Facchinetti, Alejandro Carlos Curino

Article Affiliation:

Eliana Noelia Alonso

Abstract:

D-Fraction is protein-boundβ-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell death, migration, invasion, and metastasis in MCF7 human breast cancer cells. Therefore, the purpose of the current study is to investigate if this modulation of gene expression by Maitake D-Fraction really modulates tumor progression. In the present work, we demonstrate for the first time that Maitake D-Fraction is able to act directly on mammary tumor cells, modulating different cellular processes involved in the development and progression of cancer. We demonstrate that D-Fraction decreases cell viability, increases cell adhesion, and reduces the migration and invasion of mammary tumor cells, generating a less aggressive cell behavior. In concordance with these results, wealso demonstrate that D-Fraction decreases tumor burden and the number of lung metastases in a murine model of breast cancer.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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