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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Changes on fecal microbiota in rats exposed to permethrin during postnatal development.

Abstract Source:

Environ Sci Pollut Res Int. 2016 Jun ;23(11):10930-7. Epub 2016 Feb 22. PMID: 26898931

Abstract Author(s):

Cinzia Nasuti, Maria Magdalena Coman, Robert A Olek, Dennis Fiorini, Maria Cristina Verdenelli, Cinzia Cecchini, Stefania Silvi, Donatella Fedeli, Rosita Gabbianelli

Article Affiliation:

Cinzia Nasuti

Abstract:

Alteration of the gut microbiota through diet and environmental contaminants may disturb the mammalian digestive system, leading to various diseases. Because most exposure to environmentally pyrethroid pesticides such as permethrin (PERM) occurs through the diet, the commensal gut microbiota is likely to be exposed to PERM. The study aimed at evaluating the effect of low-dose exposure to PERM in early life on the composition of fecal microbiota in rats. Over a 4-month follow-up period, fecal microbiota and short-chain fatty acids were measured in order to identify possible differences between PERM-treated rats and controls. Further in vitro antimicrobial experiments were conducted to establish the antibacterial activity of PERM against different strains to obtain Minimal Inhibitory Concentrations. The main finding focused on the reduced abundance of Bacteroides-Prevotella-Porphyromonas species, increased Enterobacteriaceae and Lactobacillus in PERM-treated rats compared to controls. Changes of acetic and propionic acid levels were registered in PERM-treated group. From in vitro studies, PERM showed higher antibacterial activity against beneficial bacteria such as Bifidobacterium and Lactobacillus paracasei, while to inhibit potential pathogens as Staphylococcus aureus and Escherichia coli PERM concentration needed to be increased. In summary, exposure to PERM could affect the fecal microbiota and could be a crucial factor contributing to the development of diseases.

Study Type : Animal Study, In Vitro Study
Additional Links
Additional Keywords : Microbiota : CK(396) : AC(101)
Problem Substances : Pesticides : CK(827) : AC(95)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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