Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

n/a
Abstract Title:

Evaluation of anti-obesity effect of Aegle marmelos leaves.

Abstract Source:

Phytomedicine. 2013 Jul 15 ;20(10):805-12. Epub 2013 Apr 28. PMID: 23632084

Abstract Author(s):

Aniket Karmase, Rahul Birari, Kamlesh K Bhutani

Article Affiliation:

Aniket Karmase

Abstract:

The study was carried out to investigate the anti-obesity effects of Aegle marmelos leaves extracts and its phytochemical constituents in vitro and in vivo. The dichloromethane (DCM), ethyl acetate (EtOAc) and n-butanol extracts of A. marmelos leaves were studied for their lipolytic effect. Lipolysis was measured by determining the amount of glycerol released at 12 h and 24 h at 50μg/ml and 100 μg/ml concentrations. Phytochemical investigation of the most active DCM extract yielded 14 compounds. The isolated compounds were evaluated for their lipolytic effects at 50 μM and 100 μM. The most active compounds, umbelliferone and esculetin were further screened for their antiobesity effects in vivo in the high fat diet (HFD) induced obese rat model. Umbelliferone and esculetin reduced body weight, total triglyceride (TG), total cholesterol (TC) and glucose level in their respective HFD groups. A. marmelos DCM extract and compounds isolated from it have the potential of counteracting the obesity by lipolysis in adipocytes.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.