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Abstract Title:

Ethanolic Extract of the Golden Oyster Mushroom, Pleurotus citrinopileatus (Agaricomycetes), Alleviates Metabolic Syndrome in Diet-Induced Obese Mice.

Abstract Source:

Int J Med Mushrooms. 2017 ;19(11):1001-1008. PMID: 29345562

Abstract Author(s):

Quanbo Chi, Guoyi Wang, Yao Sheng, Wentao Xu, Pengfei Shi, Changhui Zhao, Kunlun Huang

Article Affiliation:

Quanbo Chi

Abstract:

Pleurotus citrinopileatus is an edible medicinal mushroom rich in biomolecules and thus has a high potential for use in formulating pharmaceutical and nutraceutical products. To test its effect on body weight and glucose control, we generated diet-induced obese (DIO) C57BL/6J male mice by feeding the mice a high-fat diet (60% fat) for 8 weeks and treating them with an ethanolic P. citrinopileatus extract (PCE) at either 200 or 500 mg/kg body weight for 12 additional weeks. The results showed that PCE significantly inhibited high-fat diet-induced weight gain, fat accumulation, and glucose intolerance in the DIO mice. Moreover, the PCE had a beneficial effect on liver and kidney function. On the basis of these results, we conclude that PCE is effective in the treatment of metabolic syndrome and thus could be a good candidate for use in future pharmaceutical or nutraceutical applications.

Study Type : Animal Study

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Sayer Ji
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