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Abstract Title:

E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.

Abstract Source:

Eur Respir J. 2018 Feb ;51(2). Epub 2018 Feb 7. PMID: 29437942

Abstract Author(s):

Lisa Miyashita, Reetika Suri, Emma Dearing, Ian Mudway, Rosamund E Dove, Daniel R Neill, Richard Van Zyl-Smit, Aras Kadioglu, Jonathan Grigg

Article Affiliation:

Lisa Miyashita

Abstract:

E-cigarette vapour contains free radicals with the potential to induce oxidative stress. Since oxidative stress in airway cells increases platelet-activating factor receptor (PAFR) expression, and PAFR is co-opted by pneumococci to adhere to host cells, we hypothesised that E-cigarette vapour increases pneumococcal adhesion to airway cells.Nasal epithelial PAFR was assessed in non-vaping controls, and in adults before and after 5 min of vaping. We determined the effect of vapour on oxidative stress-induced, PAFR-dependent pneumococcal adhesion to airway epithelial cells, and on pneumococcal colonisation in the mouse nasopharynx. Elemental analysis of vapour was done by mass spectrometry, and oxidative potential of vapour assessed by antioxidant depletionThere was no difference in baseline nasal epithelial PAFR expression between vapers (n=11) and controls (n=6). Vaping increased nasal PAFR expression. Nicotine-containing and nicotine-free E-cigarette vapour increased pneumococcal adhesion to airway cellsVapour-stimulated adhesionwas attenuated by the PAFR blocker CV3988. Nicotine-containing E-cigarette vapour increased mouse nasal PAFR expression, and nasopharyngeal pneumococcal colonisation. Vapour contained redox-active metals, had considerable oxidative activity, and adhesion was attenuated by the antioxidant N-acetyl cysteine.This study suggests that E-cigarette vapour has the potential to increase susceptibility to pneumococcal infection.

Study Type : Animal Study, In Vitro Study

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