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Abstract Title:

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells.

Abstract Source:

Proc Natl Acad Sci U S A. 2018 Feb 13 ;115(7):E1560-E1569. Epub 2018 Jan 29. PMID: 29378943

Abstract Author(s):

Hyun-Wook Lee, Sung-Hyun Park, Mao-Wen Weng, Hsiang-Tsui Wang, William C Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen, Moon-Shong Tang

Article Affiliation:

Hyun-Wook Lee

Abstract:

E-cigarette smoke delivers stimulant nicotine as aerosol without tobacco or the burning process. It contains neither carcinogenic incomplete combustion byproducts nor tobacco nitrosamines, the nicotine nitrosation products. E-cigarettes are promoted as safe and have gained significant popularity. In this study, instead of detecting nitrosamines, we directly measured DNA damage induced by nitrosamines in different organs of E-cigarette smoke-exposed mice. We found mutagenic O-methyldeoxyguanosines andγ-hydroxy-1-propano-deoxyguanosines in the lung, bladder, and heart. DNA-repair activity and repair proteins XPC and OGG1/2 are significantly reduced in the lung. We found that nicotine and its metabolite, nicotine-derived nitrosamine ketone, can induce the same effects and enhance mutational susceptibility and tumorigenic transformation of cultured human bronchial epithelial and urothelial cells. These results indicate that nicotine nitrosation occurs in vivo in mice and that E-cigarette smoke is carcinogenic to the murine lung and bladder and harmful to the murine heart. It is therefore possible that E-cigarette smoke may contribute to lung and bladder cancer, as well as heart disease, in humans.

Study Type : Animal Study

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