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Abstract Title:

Electronic cigarette exposure triggers neutrophil inflammatory responses.

Abstract Source:

Respir Res. 2016 May 17 ;17(1):56. Epub 2016 Aug 17. PMID: 27184092

Abstract Author(s):

Andrew Higham, Nicholas J W Rattray, Jennifer A Dewhurst, Drupad K Trivedi, Stephen J Fowler, Royston Goodacre, Dave Singh

Article Affiliation:

Andrew Higham

Abstract:

BACKGROUND: The use of electronic cigarettes (e-cigs) is increasing and there is widespread perception that e-cigs are safe. E-cigs contain harmful chemicals; more research is needed to evaluate the safety of e-cig use. Our aim was to investigate the effects of e-cigs on the inflammatory response of human neutrophils.

METHODS: Neutrophils were exposed to e-cig vapour extract (ECVE) and the expression of CD11b and CD66b was measured by flow cytometry and MMP-9 and CXCL8 by ELISA. We also measured the activity of neutrophil elastase (NE) and MMP-9, along with the activation of inflammatory signalling pathways. Finally we analysed the biochemical composition of ECVE by ultra-high performance liquid chromatography mass spectrometry.

RESULTS: ECVE caused an increase in the expression of CD11b and CD66b, and increased the release of MMP-9 and CXCL8. Furthermore, there was an increase in NE and MMP-9 activity and an increase in p38 MAPK activation. We also identified several harmful chemicals in ECVE, including known carcinogens.

CONCLUSIONS: ECVE causes a pro-inflammatory response from human neutrophils. This raises concerns over the safety of e-cig use.

Study Type : Human In Vitro
Additional Links
Adverse Pharmacological Actions : Inflammatory : CK(298) : AC(83)

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