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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Demethoxycurcumin ameliorates rotenone-induced toxicity in rats.

Abstract Source:

Front Biosci (Elite Ed). 2019 01 1 ;11:1-11. Epub 2019 Jan 1. PMID: 30468633

Abstract Author(s):

Muthu Ramkumar, Srinivasagam Rajasankar, William Moses Swaminathan Johnson, Kaliyaperumal Prabu, Veerappan Venkatesh Gobi

Article Affiliation:

Muthu Ramkumar

Abstract:

Rotenone, an environmental toxin, is used to induce neurodegeneration in both the cellular and animal model of Parkinson's disease. Demethoxycurcumin (DMC), derivative of curcumin has been reported to have antioxidant and anti-inflammatory characteristics inandPD conditions. The present study was aimed to evaluate the efficacy of DMC in the management of neurodegeneration in PD. Male Wistar rats were radomized and divided into control, rotenone, DMC +rotenone and rotenone alone treated animals. Pre-treatment with DMC one hour prior to the rotenone injection, attenuated the motor and non-motor deficits. Western blot analysis indicated that the administration of DMC to PD rats easedthe protein expression of dopaminergic and apoptotic indices. These findings showed that DMC effects on ameliorating the PD symptoms induced by rotenone might be associated with the neuroprotective and antioxidant effects of this compound.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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