Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

n/a
Abstract Title:

Impact of Cyanocobalamin and Methylcobalamin on Inflammatory Bowel Disease and the Intestinal Microbiota Composition.

Abstract Source:

J Agric Food Chem. 2018 Dec 20. Epub 2018 Dec 20. PMID: 30572705

Abstract Author(s):

Xuan Zhu, Shasha Xiang, Xiao Feng, Huanhuan Wang, Shiyi Tian, Yuanyuan Xu, Lihua Shi, Lu Yang, Mian Li, Yubiao Shen, Jie Chen, Yuewen Chen, Jianzhong Han

Article Affiliation:

Xuan Zhu

Abstract:

Patients with inflammatory bowel disease (IBD) are usually advised to supplement various types of vitamin B12, since vitamin B12 is generally absorbed in colon. Thus, in the current study, the influence of cyanocobalamin (CNCBL) or methylcobalamin (MECBL) ingestion on IBD symptoms will be investigated. Then, whether and how the application of various cobalamins would modify the taxonomic and functional composition of the gut microbiome in mice will be examined carefully. Dextran sulfate sodium-induced IBD mice were treated with MECBL or CNCBL; disease activity index (DAI) scores and intestinal inflammatory condition of mice were evaluated. Faecal samples were collected; microbiota composition was determined with a 16s rRNA analysis, functional profiles were predicted by PICRUSt and short-chain fatty acids were measured. The consequence of higher relative abundances of Enterobacteriaceae and isomeric short chain fatty acids by cobalamins treatment revealed that a high concentration of CNCBL, but not MECBL, supplementation obviously aggravated IBD. A microbial ecosystem rich in Escherichia/Shigella and low in Lactobacillus, Blautia, and Clostridium XVIII was observed in IBD mice after a high concentration of CNCBL supplementation. In cobalamin-dependent enzymes, CNCBL was more efficient in adenosyl-cobalamin system than MECBL, vice versa in MECBL system. The distinct effects of various cobalamins were associated with the distribution and efficiency of vitamin B12-dependent riboswitches. CNCBL had a strong inhibitory effect on all riboswitches, especially on btuB and pocR riboswitches from Enterobacteriaceae. CNCBL aggravated IBD via enhancing the proportion of Enterobacteriaceae organisms through riboswitch and enzyme systems. The present study provides a critical reference for offering a suitable amount and type of cobalamin during a symbiotic condition.

Study Type : Animal Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.