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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Curcumin targets fibroblast-tumor cell interactions in oral squamous cell carcinoma.

Abstract Source:

Exp Cell Res. 2012 Dec 13. Epub 2012 Dec 13. PMID: 23247073

Abstract Author(s):

József Dudás, Alexandra Fullár, Angela Romani, Christian Pritz, Ilona Kovalszky, Volker Hans Schartinger, Georg Mathias Sprinzl, Herbert Riechelmann

Article Affiliation:

Department of Otorhinolaryngology and Head and Neck Surgery, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. Electronic address: jozsef.dudas@i-med.ac.at.

Abstract:

Co-culture of periodontal ligament fibroblasts (PDLs) and SCC-25 oral squamous carcinoma cells (OSCC) results in conversion of PDLs into carcinoma-associated fibroblasts (CAFs) and induces epithelial-to mesenchymal transition (EMT) of OSCC tumor cells. We hypothesized that Curcumin targets this dynamic mutual interaction between CAFs and tumor cells. Normal and 2µM Curcumin-treated co-culture were performed for 4 days, followed by analysis of tumor cell invasivity, mRNA/protein expression of EMT-markers and mediators, activity measure of matrix metalloproteinase 9 (MMP-9), and western blot analysis of signal transduction in tumor cells and fibroblasts. InCurcumin-treated co-culture, in tumor cells, the levels of nuclear factor κB (NFκBα) and early response kinase (ERK)- decreased, in fibroblasts, integrin αv protein synthesis decreased compared to corresponding cells in normal co-culture. The signal modulatory changes induced by Curcumin causeddecreased release of EMT-mediators in CAFs and reversal of EMT in tumor cells, which was associated with decreased invasion. These data confirm the palliative potential of Curcumin in clinical application.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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