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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Synergistic antibacterial activity of Curcumin with antibiotics against Staphylococcus aureus.

Abstract Source:

Pak J Pharm Sci. 2015 Nov ;28(6):2109-14. PMID: 26639480

Abstract Author(s):

Sin-Yeang Teow, Syed Atif Ali

Article Affiliation:

Sin-Yeang Teow

Abstract:

This study evaluated the synergistic antibacterial activity of Curcumin with 8 different antibiotic groups. Two reference, one clinical and ten environmental strains of Staphylococcus aureus (S. aureus) were tested. Disc diffusion assay with 25μg/mL Curcumin demonstrated synergism in combination with a majority of tested antibiotics against S. aureus. However, checkerboard micro dilution assay only showed synergism, fractional inhibitory concentration index (FICI)<0.5 in three antibiotics i.e. Gentamicin, Amikacin, and Ciprofloxacin. Other antibiotics showed indifferent interactions but no antagonism was observed. In time-kill curve, appreciable reduction of bacterial cells was also observed in combination therapy (Curcumin + antibiotics) compared to monotherapy (Curcumin or antibiotic(s) alone). The antibiotics with higher synergistic interaction with Curcumin are arranged in a decreasing order: Amikacin>Gentamicin>Ciprofloxacin.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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