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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective.

Abstract Source:

Respir Med. 2008 Jun;102(6):840-4. Epub 2008 Mar 4. PMID: 21158690

Abstract Author(s):

Paul A Lapchak

Article Affiliation:

Cedars-Sinai Medical Center, Department of Neurology, Davis Research Building, D-2091, 110 N. George Burns Road, Los Angeles, CA 90048, USA. Paul.Lapchak@cshs.org

Abstract:

IMPORTANCE OF THE FIELD: Curcumin has been investigated in preclinical and translational stroke models because of its pleiotropic 'neuroprotective' activities. Since curcumin has poor blood-brain barrier (BBB) penetration following acute administration, creative medicinal chemistry has been used to modify the parent curcumin molecule, resulting in second generation curcuminoids, which have enhanced BBB penetration, improved pharmacokinetics and interact with multiple viable targets to treat stroke.

AREAS COVERED IN THIS REVIEW: This review covers epidemiological, preclinical and translational data published between 2002 and 2010.

WHAT THE READER WILL GAIN: There are two main goals: First, epidemiological data comparing the incidence of stroke in North America to that of India, a country where curcumin is a main-stay of the diet is presented. Second, the pharmacological characteristics of curcuminoids are detailed to determine if they should be further studied in translational stroke models for safety and efficacy prior to initiating clinical trials.

TAKE HOME MESSAGE: Curcumin and curcuminoids are neuroprotective in a variety of preclinical stroke models. The novel multi-target curcuminoid, CNB-001, has a superior safety and pharmacokinetic profile and should be further developed as an acute monotherapy or to be used in conjunction with thrombolytics for acute ischemic stroke.

Study Type : Review

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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