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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Curcumin affectsβ-catenin pathway in hepatic stellate cell in vitro and in vivo.

Abstract Source:

J Pharm Pharmacol. 2014 Nov ;66(11):1615-22. Epub 2014 Jun 19. PMID: 24945564

Abstract Author(s):

Lei Cui, Xin Jia, Qian Zhou, Xuguang Zhai, Yajun Zhou, Huixia Zhu

Article Affiliation:

Lei Cui

Abstract:

OBJECTIVES: Emerging evidence indicates that Wnt/β-catenin pathway is linked to the fibrosis of different organs including liver fibrosis. β-Catenin promotes hepatic stellate cells (HSCs) activation, a key event in the development of liver fibrosis, and has emerged as a novel mediator of fibrosis. Curcumin, a natural active ingredient derived from turmeric, possesses an inhibitory effect on liver fibrosis. This study is aimed to examine whether curcumin affects β-catenin expression/activity in HSCs and explores the underlying mechanisms.

METHODS: The researchers used Western blot, real-time PCR, transfection assay and electrophoretic mobility shift assay and employed cultured HSCs and rat model of liver injury.

KEY FINDINGS: Results showed that curcumin could reduceβ-catenin protein level in HSCs in vitro and in vivo. Both β-catenin transactivation activity and DNA-binding activity were suppressed by curcumin. Moreover, nuclear β-catenin protein level was decreased by curcumin treatment. Further experiments suggested that delta-like homologue 1 contributed to curcumin inhibition of β-catenin transactivation activity in cultured HSCs.

CONCLUSIONS: Curcumin affectsβ-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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