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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Crude caffeine reduces memory impairment and amyloidβ(1-42) levels in an Alzheimer's mouse model.

Abstract Source:

Food Chem. 2012 Dec 1 ;135(3):2095-102. Epub 2012 Jun 29. PMID: 22953961

Abstract Author(s):

Yi-Fang Chu, Wen-Han Chang, Richard M Black, Jia-Ren Liu, Pradoldej Sompol, Yumin Chen, Huilin Wei, Qiuyan Zhao, Irene H Cheng

Article Affiliation:

Yi-Fang Chu

Abstract:

Alzheimer's disease (AD), a chronic neurodegenerative disorder associated with the abnormal accumulations of amyloidβ (Aβ) peptide and oxidative stress in the brain, is the most common form of dementia among the elderly. Crude caffeine (CC), a major by-product of the decaffeination of coffee, has potent hydrophilic antioxidant activity and may reduce inflammatory processes. Here, we showed that CC and pure caffeine intake had beneficial effects in a mouse model of AD. Administration of CC or pure caffeine for 2months partially prevented memory impairment in AD mice, with CC having greater effects than pure caffeine. Furthermore, consumption of CC, but not pure caffeine, reduced the Aβ(1-42) levels and the number of amyloid plaques in the hippocampus. Moreover, CC and caffeine protected primary neurons from Aβ-induced cell death and suppressed Aβ-induced caspase-3 activity. Our data indicate that CC may contain prophylactic agents against the cell death and the memory impairment in AD.

Study Type : Transgenic Animal Study
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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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