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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Crocin reduces the inflammation response in rheumatoid arthritis.

Abstract Source:

Biosci Biotechnol Biochem. 2017 May ;81(5):891-898. PMID: 28388359

Abstract Author(s):

Xiang Li, Chao Jiang, Wenyong Zhu

Article Affiliation:

Xiang Li

Abstract:

This study is to determine the role and mechanism of crocin in rheumatoid arthritis (RA). Totally 60 Wistar SD rats were randomly divided into control group, RA model group, methotrexate group, crocin high dose, middle dose, and low dose groups. The paw swelling degree, arthritis score, thymus and spleen index, the mRNA and protein levels of iNOS, and the serum content of TNF-α, IL-1β, and IL-6 were evaluated. Crocin treatment significantly alleviated the paw swelling of RA rats. The arthritis score in crocin treatment groups was significantly lower than that in RA model group. Additionally, the thymus index, but not the spleen index, declined remarkably in crocin treatment groups than in RA model group. Besides, crocin administration significantly reduced the iNOS production and the serum content of TNF-α, IL-1β, and IL-6. Crocin may exert potent anti-RA effects through inhibiting cytokine.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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