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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Effects of chlorpyrifos on the gut microbiome and urine metabolome in mouse (Mus musculus).

Abstract Source:

Chemosphere. 2016 Jun ;153:287-93. Epub 2016 Mar 26. PMID: 27018521

Abstract Author(s):

Yanping Zhao, Yan Zhang, Guoxiang Wang, Ruiming Han, Xianchuan Xie

Article Affiliation:

Yanping Zhao

Abstract:

In this study, the toxic effects of clorpyrifos (CPF) on the gut microbiome and related urine metabolome in mouse (Mus musculus) were investigated. Mice were exposed to a daily dose of 1 mg kg(-1) bodyweight of CPF for 30 d. As a result, CPF significantly altered the gut microbiota composition in terms of the relative abundance of key microbes. Meanwhile, CPF exposure induced the alterations of urine metabolites related to the metabolism of amino acids, energy, short-chain fatty acids (SCFAs), phenyl derivatives and bile acids. High correlations were observed between perturbed gut microbiome and altered metabolic profiles. These perturbations finally resulted in intestinal inflammation and abnormal intestinal permeability, which were also confirm by the histologic changes in colon and remarkable increase of lipopolysaccharide (LPS) and diamine oxidase (DAO) in the serum of CPF-treated mice. Our findings will provide a new perspective to reveal the mechanism of CPF toxicity.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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