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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

Abstract Source:

J Nat Prod. 1994 Jan;57(1):42-51. PMID: 8158164

Abstract Author(s):

C Q Hu, K Chen, Q Shi, R E Kilkuskie, Y C Cheng, K H Lee

Article Affiliation:

Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.

Abstract:

An active anti-HIV principle, acacetin-7-O-beta-D-galactopyranoside, has been isolated from Chrysanthemum morifolium. Seven additional flavonoids isolated from this plant, 13 known related flavonoids, and 14 synthetic flavonoids were also evaluated as inhibitors of HIV replication in H9 cells. A known flavone, chrysin, was found to be the most promising compound in this series. Flavonoids with hydroxy groups at C-5 and C-7 and with a C-2-C-3 double bond were more potent inhibitors of HIV growth. In general, the presence of substituents (hydroxyl and halogen) in the B-ring increased toxicity and/or decreased activity.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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