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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice.

Abstract Source:

Food Chem Toxicol. 2011 Jul 26. Epub 2011 Jul 26. PMID: 21820028

Abstract Author(s):

Mary L S Queiroz, Michelle C da Rocha, Cristiane O Torello, Julia de Souza Queiroz, Claudia Bincoletto, Marcelo A Morgano, Miriam R Romano, Edgar J Paredes-Gamero, Christiano M V Barbosa, Andrana K Calgarotto

Article Affiliation:

Departamento de Farmacologia/Hemocentro, Faculdade de Ciências Médicas, FCM Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil.

Abstract:

Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit(+)Lin(-)), granulocyte-macrophage progenitors (Gr1(+)Mac1(+)) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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