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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Neurological manifestations of celiac disease.

Abstract Source:

Arq Neuropsiquiatr. 2004 Dec ;62(4):969-72. Epub 2004 Dec 15. PMID: 15608953

Abstract Author(s):

José Ibiapina Siqueira Neto, Ana Carolina Leite Vieira Costa, Francisco George Magalhães, Gisele Sampaio Silva

Article Affiliation:

Department of Internal Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.

Abstract:

Celiac disease (CD/ Nontropicalsprue, gluten-sensitive enteropathy) is a malabsortive condition in which an allergic reaction to the cereal grain-protein gluten (present in wheat, rye and barley) causes small intestine mucosal injury. The onset is in the first four decades of life, with a female to male ratio of 2:1. It may be associated with a wide spectrum of neurological manifestations including cerebellar ataxia, epileptic seizures, dementia, neuropathy, myopathy and multifocal leucoencephalopathy. We report three patients with neurological manifestations related with CD: one with cerebellar ataxia, one with epilepsy and one with cognitive impairment. The diagnosis of CD was confirmed by serologic tests (antiendomysial and antigliadin antibodies) and biopsy of the small intestine. In two patients the neurological symptoms preceded the gastrointestinal abnormalities and in all of them gluten restriction failed to improve the neurological disability. CONCLUSION: CD should be ruled out in the differential diagnosis of neurological dysfunction of unknown cause, including ataxia, epilepsy and dementia. A gluten free diet, the mainstay of treatment, failed to improve the neurological disability.

Study Type : Review

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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