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Cayenne has anti-fungal properties. - GreenMedInfo Summary

Abstract Title:

CAY-1, a novel antifungal compound from cayenne pepper.

Abstract Source:

Med Mycol. 2003 Feb;41(1):75-81. PMID: 12627807

Abstract Author(s):

S Renault, A J De Lucca, S Boue, J M Bland, C B Vigo, C P Selitrennikoff

Article Affiliation:

MycoLogics, Inc., Aurora, Colorado 80010, USA.

Abstract:

CAY-1, a novel saponin from Capsicum frutescens (commercially known as cayenne pepper) was investigated to determine its in vitro antifungal activity, mechanism of action and mammalian cell cytotoxicity. CAY-1 was active against 16 different fungal strains, including Candida spp. and Aspergillus fumigatus [minimum inhibitory concentrations (MIC) ranging from 4 to 16 microg ml(-1)], and was especially active against Cryptococcus neoformans (90% inhibition at 1 microg ml(-1)). Synergistic activity was also observed between CAY-1 and amphotericin B against Candida albicans and A. fumigatus. No significant cytotoxicity was demonstrated when CAY-1 was tested against 55 mammalian cell lines at up to 100 microg ml(-1). Importantly, CAY-1 appears to act by disrupting the membrane integrity of fungal cells.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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