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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Cannabinoids in intestinal inflammation and cancer.

Abstract Source:

Pharmacol Res. 2009 Aug ;60(2):117-25. Epub 2009 Mar 18. PMID: 19442536

Abstract Author(s):

Angelo A Izzo, Michael Camilleri

Article Affiliation:

Angelo A Izzo

Abstract:

Emerging evidence suggests that cannabinoids may exert beneficial effects in intestinal inflammation and cancer. Adaptive changes of the endocannabinoid system have been observed in intestinal biopsies from patients with inflammatory bowel disease and colon cancer. Studies on epithelial cells have shown that cannabinoids exert antiproliferative, antimetastatic and apoptotic effects as well as reducing cytokine release and promoting wound healing. In vivo, cannabinoids - via direct or indirect activation of CB(1) and/or CB(2) receptors - exert protective effects in well-established models of intestinal inflammation and colon cancer. Pharmacological elevation of endocannabinoid levels may be a promising strategy to counteract intestinal inflammation and colon cancer.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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