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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.

Abstract Source:

Biosci Biotechnol Biochem. 2008 Dec;72(12):3148-57. Epub 2008 Dec 7. PMID: 19060399

Abstract Author(s):

Satoshi Ishii, Takafumi Katsumura, Chikara Shiozuka, Keisuke Ooyauchi, Kunito Kawasaki, Shigenobu Takigawa, Tatsunobu Fukushima, Yoshihiko Tokuji, Mikio Kinoshita, Masao Ohnishi, Mika Kawahara, Kiyoshi Ohba

Abstract:

In conducting an in vitro screening of ethanol extracts from various natural foods using a human colon cancer cell line (CoLoTC cells), an extract of buckwheat sprouts (ExtBS) was found to express significant anti-inflammatory activity. The anti-inflammatory activity of ExtBS was confirmed by oral administration of lipopolysaccharide (LPS) to mice. Inflammatory cytokines (interleukin 6 and tumor necrosis factor alpha) were markedly up-regulated in the spleen and liver from LPS-administrated mice, and combinatory treatment with LPS and ExtBS decreased up-regulation of them in both cytokines. Both serum cytokine levels corresponded to their gene expressions in tissues, but no anti-inflammatry effect in mice was observed when ExtBS was treated intraperitoneally. ExtBS oral administration also showed protective activity as to hepatic injury induced by galactosamine/LPS treatment. Based on these data, we suggest that ExtBS contains anti-inflammatory compounds.

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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