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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment: A Pilot Study.

Abstract Source:

J Invest Dermatol. 2012 Aug 30. Epub 2012 Aug 30. PMID: 22931923

Abstract Author(s):

Anne Lynn S Chang, Patrick H Bitter, Kun Qu, Meihong Lin, Nicole A Rapicavoli, Howard Y Chang

Article Affiliation:

Department of Dermatology, Stanford University School of Medicine, Redwood City, California, USA.

Abstract:

Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3'-end sequencing for expression quantification ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed"skin aging"), and the impact of broadband light (BBL) treatment. We find that skin aging was associated with a significantly altered expression level of 2,265 coding and noncoding RNAs, of which 1,293 became"rejuvenated"after BBL treatment; i.e., they became more similar to their expression level in youthful skin. Rejuvenated genes (RGs) included several known key regulators of organismal longevity and their proximal long noncoding RNAs. Skin aging is not associated with systematic changes in 3'-end mRNA processing. Hence, BBL treatment can restore gene expression pattern of photoaged and intrinsically aged human skin to resemble young skin. In addition, our data reveal, to our knowledge, a previously unreported set of targets that may lead to new insights into the human skin aging process.Journal of Investigative Dermatology advance online publication, 30 August 2012; doi:10.1038/jid.2012.287.

Study Type : Review
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Therapeutic Actions : Light Therapy : CK(154) : AC(31)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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