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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function.

Abstract Source:

Nutrients. 2018 Jun 2 ;10(6). Epub 2018 Jun 2. PMID: 29865234

Abstract Author(s):

Dawei Fan, Yassar Alamri, Karen Liu, Michael MacAskill, Paul Harris, Margaret Brimble, John Dalrymple-Alford, Tim Prickett, Oliver Menzies, Andrew Laurenson, Tim Anderson, Jian Guan

Article Affiliation:

Dawei Fan

Abstract:

BACKGROUND: Insulin-like growth factor-1 (IGF-1) function is impaired in Parkinson disease. Cyclic glycine-proline (cGP), a metabolite of IGF-1, is neuroprotective through improving IGF-1 function. Parkinson disease patients score lower on Hospital-associated Anxiety and Depression Scale after supplementing blackcurrant anthocyanins (BCA), which may be associated with IGF-1 function. We evaluated the changes of cGP and IGF-1 before and after the supplementation.

METHODS: Plasma and cerebrospinal fluid (CSF) were collected from 11 male patients before and after 28 day supplementation of BCA. The concentrations of IGF-1, IGF binding protein (IGFBP)-3, and cGP were measured using ELISA and HPLC-MS assays. The presence of cGP in the BCA was evaluated.

RESULTS: cGP presented in the BCA. BCA supplementation increased the concentration of cGP (<0.01), but not IGF-1 and IGFBP-3 in the CSF. CSF concentration of cGP was correlated with plasma concentration of cGP (R = 0.68,= 0.01) and cGP/IGF-1 molar ratio (R = 0.66,= 0.01). The CSF/plasma ratio was high in cGP and low in IGF-1 and IGFBP-3.

CONCLUSION: cGP is a natural nutrient to the BCA. The increased CSF cGP in Parkinson disease patients may result from the central uptake of plasma cGP. Given neurotrophic function, oral availability, and effective central uptake of cGP, the BCA has the potential to be developed to treat neurological conditions with IGF-1 deficiency.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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