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Depression: 21st Century Solutions + The Dark Side of Wheat

Article Publish Status: FREE
Abstract Title:

Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway.

Abstract Source:

J Neuroinflammation. 2015 ;12:124. Epub 2015 Jun 26. PMID: 26112466

Abstract Author(s):

Sun Mi Gu, Mi Hee Park, Chul Ju Hwang, Ho Sueb Song, Ung Soo Lee, Sang Bae Han, Ki Wan Oh, Young Wan Ham, Min Jong Song, Dong Ju Son, Jin Tae Hong

Article Affiliation:

Sun Mi Gu

Abstract:

BACKGROUND: Accumulation of beta-amyloid and neuroinflammation trigger Alzheimer's disease. We previously found that lipopolysaccharide (LPS) caused neuroinflammation with concomitant accumulation of beta-amyloid peptides leading to memory loss. A variety of anti-inflammatory compounds inhibiting nuclear factor kappaB (NF-κB) activation have showed efficacy to hinder neuroinflammation and amyloidogenesis. We also found that bee venom (BV) inhibits NF-κB.

METHODS: A mouse model of LPS-induced memory loss used administration of BV (0.8 and 1.6μg/kg/day, i.p.) to ICR mice for 7 days before injection of LPS (2.5 mg/kg/day, i.p.). Memory loss was assessed using a Morris water maze test and passive avoidance test. For in vitro study, we treated BV (0.5, 1, and 2 μg/mL) to astrocytes and microglial BV-2 cells with LPS (1 μg/mL).

RESULTS: We found that BV inhibited LPS-induced memory loss determined by behavioral tests as well as cell death. BV also inhibited LPS-induced increases in the level of beta-amyloid (Aβ), β-and γ-secretases activities, NF-κB and its DNA-binding activity and expression of APP, and BACE1 and neuroinflammation proteins (COX-2, iNOS, GFAP and IBA-1) in the brain and cultured cells. In addition, pull-down assay and molecular modeling showed that BV binds to NF-κB.

CONCLUSIONS: BV attenuates LPS-induced amyloidogenesis, neuroinflammation, and therefore memory loss via inhibiting NF-κB signaling pathway. Thus, BV could be useful for treatment of Alzheimer's disease.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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