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Abstract Title:

3-phenylacetylamino-2,6-piperidinedione inhibition of rat Nb2 lymphoma cell mitogenesis.

Abstract Source:

Proc Soc Exp Biol Med. 1991 Sep ;197(4):404-8. PMID: 1871151

Abstract Author(s):

J C Wood, J A Copland, T G Muldoon, L B Hendry

Article Affiliation:

Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912.

Abstract:

3-Phenylacetylamino-2,6-piperidinedione (A10), an amino acid analog, has been reported to possess antineoplastic activity against certain neoplastic tissues. The antimitogenic properties of A10 were studied by determining its effect on prolactin (PRL)- and interleukin 2 (IL-2)-stimulated mitogenic responses in the rat Nb2 lymphoma cell line. The addition of A10 (1-12 mM) to PRL (0.4 ng/ml)-stimulated cells inhibited growth in a dose-dependent manner. DNA synthesis patterns studied by thymidine incorporation demonstrated that A10 was significantly inhibitory (25% at 20 hr; 50% at 40 hr, P less than 0.01). IL-2 stimulation of mitogenesis was also sensitive to A10 inhibition. The inhibition of PRL stimulated mitogenesis was reversible when A10 was removed after 24 hr of culture and A10 showed no toxicity in a chromium release assay. These data suggest that A10 effects may be cytostatic, rather than cytotoxic.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685)

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Sayer Ji
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