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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Cytotoxic indole alkaloids against human leukemia cell lines from the toxic plant Peganum harmala.

Abstract Source:

Toxins (Basel). 2015 Nov 3 ;7(11):4507-18. Epub 2015 Nov 3. PMID: 26540074

Abstract Author(s):

Chunhua Wang, Zhenxue Zhang, Yihai Wang, Xiangjiu He

Article Affiliation:

Chunhua Wang

Abstract:

Bioactivity-guided fractionation was used to determine the cytotoxic alkaloids from the toxic plant Peganum harmala. Two novel indole alkaloids, together with ten known ones, were isolated and identified. The novel alkaloids were elucidated to be 2-(indol-3-yl)ethyl-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2) and 3-hydroxy-3-(N-acetyl-2-aminoethyl)-6-methoxyindol-2-one (3). The cytotoxicity against human leukemia cells was assayed for the alkaloids and some of them showed potent activity. Harmalacidine (compound 8, HMC) exhibited the highest cytotoxicity against U-937 cells with IC50 value of 3.1 ± 0.2 μmol/L. The cytotoxic mechanism of HMC was targeting the mitochondrial and protein tyrosine kinase signaling pathways (PTKs-Ras/Raf/ERK). The results strongly demonstrated that the alkaloids from Peganum harmala could be a promising candidatefor the therapy of leukemia.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Apoptotic, leukemia, Syrian rue

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Depression: 21st Century Solutions + The Dark Side of Wheat

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